Michael Ausiello of Entertainment Weekly has some interesting Grey's Anatomy spoilers in his Q&A today, and even a direct quote from Shonda Rhimes about the Izzie-Denny story line.

Read on and follow the jump for the latest on what's to come ...

Q: What the hell is going on with Grey's Anatomy's Denny and Izzie?

A: Don't be so quick to judge, people. Who among us hasn't gone to first base with a dead ex at least once in our lives? Exactly.

Q: Okay, I'm officially worried that Izzie really does have a brain tumor and Shonda Rhimes is paving the way for Katherine Heigl's departure at the end of the season.

A: Hold on ... I've got Shonda Rhimes on the line ... She says she heard through the grapevine that I've been flooded with hundreds of e-mails from mostly irate and confused Grey's Anatomy fans wondering WTF is going on with this bizarre love story between a dead Denny (Jeffrey Dean Morgan) and an alive Izzie ... The show's creator and executive producer says she'd like to address readers directly via this exclusive statement ...

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Why is Izzie still seeing things (and by things, we of course mean Denny)? And what happens when the interns' surgical experimenting goes horrifically wrong?

We've had a look at the photo gallery, now here are a pair of promos for Thursday's Grey's Anatomy, entitled "In the Midnight Hour." Sneak peeks still to come ...

In the Midnight Hour Promo #1

What do you think? Share your thoughts, then follow the jump for a second, slightly different preview of this drama-packed episode, the ninth of Season Five ...

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Below is a little photo gallery from this Thursday's new episode, "In the Midnight Hour." Click to enlarge any of the thumbails for a better look. Promos and sneak peeks to come!

In today's edition of "Guess who's leaving Grey's Anatomy now," Michael Ausiello of Entertainment Weekly reports that Janina Gavankar has departed the show.

Did you even know she was on it?

The L Word alum, who joined the Grey's Anatomy cast in September as one of several new Seattle Grace interns, has left the show after just two episodes.

Per one insider, the role turned out to be smaller than Gavankar had hoped. Without a guarantee that her part would grow, the actress chose to move on.

In more significant cast news, rumors - just rumors, we emphasize - continue to circulate about Sara Ramirez and whether Callie's days at Seattle Grace are numbered.

When we first reported the news that Jeffrey Dean Morgan would be back on Grey's Anatomy this November, we assumed it was just for another fleeting cameo.

Now it's looking like the handsome actor who plays the late Denny Duquette, Jr., could be sticking around for the foreseeable future - and may well turn out to be the "surprising" love interest for Izzie that Shonda Rhimes promised in the offseason.

How long will Denny haunt Izzie and where the heck is this even going?

As for the first part, Michael Ausiello of Entertainment Weekly says Jeffrey Dean Morgan will be in at least five episodes of Grey's Anatomy. Whether that's five from the start of his recent stint or five more as of now is unclear - but he's not going anywhere.

As far as where the story is headed, the most logical theory is that Shonda Rhimes is indeed giving Izzie a brain tumor, as was rumored months ago, and which would or could grant Katherine Heigl's (never publicly stated) wish to make movies full time.

But who says this story has to be logical, right? As Grey's Anatomy writer Stacy McKee opined on the show's writers blog after "These Ties That Bind":

"Maybe this is one connection that gets to defy all... common sense. Maybe it just gets to be. Even if it does seem too good to be true."

There has been a lot of speculation in the last couple of weeks that Sara Ramirez (Dr. Callie Torres) will be leaving the cast of Grey's Anatomy later this season.

We have not reported these rumors to you so far because they are only that - speculation. But given the sheer amount of attention they're generating, we're going to now. Nothing you read below is confirmed, but some of the rumors and theories are:

• That Sara Ramirez will be departing Grey's Anatomy after episode 15 or 16. This past week's episode, "These Ties That Bind," was the eighth of Season 5.
• That Brooke Smith is not the only one being let go from the show, and given her relationship with Smith's character, Erica Hahn, Sara Ramirez is next.
• That Sara might be headed back to Broadway, where she was a star.
• That Melissa George's character Sadie was brought in (or possibly re-written after Smith's departure) for Eric Dane's character, Mark Sloan, because the ABC executives wanted a different, fairly big-name actress for his love interest.

Again, this is pure conjecture and nothing more. But What do you think of these Grey's Anatomy rumors - and have you heard any others? Share with us ...

Amid rumors of her Grey's Anatomy character getting a brain tumor or going all Ghost Whisperer on us (see theories in our Round Table), Katherine Heigl was all smiles as she dined with her husband Josh Kelley at the Desert Rose restaurant in the Los Feliz area of L.A ...

NOT FEELING GREY: Regardless of what's going on with Izzie Stevens or Katherine Heigl's contract, the actress was certainly in good spirits. [Photo Credit: Splash News Online]

While fans gather in our Grey's Anatomy forum to discuss each character, couple and plot twist, the Insider staff comes together to talk about some of the best moments and share opinions regarding the latest episode of our favorite medical drama.

Topics for our Round Table for "These Ties That Bind" include the show's new direction, Cristina and Owen, Little Sloan and Little Grey, and the lack of MerDer drama ...

1. So, Grey's Anatomy appears to be the new Ghost Whisperer. Are you happy with this direction?

McCritic: No. I'm all for fairy tale love... in fairy tales! Shonda and the writers can't take pride in how realistic their show depicts relationships, only to create a story line based around interaction with a ghost.

missingBurke: I'm all for more Denny Duquette, but this development strains credulity.

iheartizzie: Hallucinations occur when an individual has a tumor in the temporal lobe of one's brain. Therefore, I can only imagine this angle is a way for the show to slowly reveal Izzie's long-rumored brain tumor. If that's the case, you gotta hand it to the writers for crafting an interesting (and handsome!) way to bring on the disease.

Has Dr. Izzie Stevens (Katherine Heigl) officially lost it?

2. Will Mark heed Derek's advice and keep "Little Sloan" away from "Little Grey?"

iheartizzie: Unlikely. That's like someone on The Bachelor actually finding love on the show.

McCritic: I'm actually gonna say yes. Via his relationship with Callie, a softer side has developed to Mark. He'll respect his best friend's wishes.

missingBurke: Of course not. Mark isn't a bad guy, but the part of the body he thinks with isn't exactly in his head.

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Welcome to the 132nd edition of the Grey's Anatomy Insider Caption Contest!

To see who won last week, and to read the full list of entries sent in, click here.

Then get ready for an all-new Caption Contest! All you do is think of your best caption(s) for the Grey's Anatomy photo below, click "comments" and post away!

Happy Friday, Grey's Anatomy fans.

There's a lot to say about last night's episode, but in case you need a refresher first - or just want to relive the action - our episode guide to "These Ties That Bind" is live.

Our photo and video sections contain some great pics and clips, and our pages dedicated to last night's quotes and music (works in progress) should help you remember or figure out the song / line that you loved. Our staff Round Table discussion is still to come, too.

The incomparable Denny Duquette, Jr., played by Jeffrey Dean Morgan.

As always, our Grey's Anatomy forum is open for discussion, and your comments are welcome on any of the articles on our site. Share your thoughts and views on the things you loved and hated with fellow members of the web's #1 Grey's Anatomy community!